Target intelligence / Profile preview

Phenylalanine ammonia lyase (PAL)

Target: PAL
Molecular classification: Enzyme

Overview

Phenylalanine ammonia lyase (PAL) is an enzyme (EC 4.3.1.24) that catalyzes the nonoxidative deamination of L-phenylalanine to produce trans-cinnamic acid and ammonia. This reaction represents the first committed step in the phenylpropanoid pathway, which is crucial for the biosynthesis of a wide range of secondary metabolites in plants. It is being investigated as an enzyme replacement therapy for phenylketonuria (PKU) to help degrade excess phenylalanine and has been explored experimentally in cancer therapy.

Mechanism of action

Catalyzes the nonoxidative deamination of L-phenylalanine to produce trans-cinnamic acid and ammonia, reducing phenylalanine levels.

Biological functions

CatalysisPhenylpropanoid biosynthesisSecondary metabolite production

Disease associations

Phenylketonuria (PKU)Cancer (experimental)

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