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Phenylalanine ammonia lyase (PAL)
- Target
- PAL
- Molecular classification
- Enzyme
01
Overview
Phenylalanine ammonia lyase (PAL) is an enzyme (EC 4.3.1.24) that catalyzes the nonoxidative deamination of L-phenylalanine to produce trans-cinnamic acid and ammonia. This reaction represents the first committed step in the phenylpropanoid pathway, which is crucial for the biosynthesis of a wide range of secondary metabolites in plants. It is being investigated as an enzyme replacement therapy for phenylketonuria (PKU) to help degrade excess phenylalanine and has been explored experimentally in cancer therapy.
02
Mechanism of action
Catalyzes the nonoxidative deamination of L-phenylalanine to produce trans-cinnamic acid and ammonia, reducing phenylalanine levels.
03
Biological functions
CatalysisPhenylpropanoid biosynthesisSecondary metabolite production
04
Disease associations
Phenylketonuria (PKU)Cancer (experimental)
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