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Phenylethanolamine N-methyltransferase (PNMT)
- Target
- PNMT
- Molecular classification
- Enzyme, Methyltransferase, NNMT/PNMT/TEMT family
01
Overview
Phenylethanolamine N-methyltransferase (PNMT) is an enzyme primarily found in the adrenal medulla, where it catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline), representing the final step in catecholamine biosynthesis. PNMT is also expressed in select neurons within the human brain and certain populations of cardiomyocytes. It is essential for the stress response and involved in the regulation of various autonomic functions. Alterations in PNMT expression have been implicated in hypertension.
- Other names
- PENTnoradrenaline N-methyltransferasephenylethanolamine N-methylase
02
Mechanism of action
Catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to norepinephrine, forming epinephrine.
03
Biological functions
Catecholamine biosynthesisMethylationStress response regulationRegulation of heart rateRegulation of blood pressureRegulation of blood glucose levels
04
Disease associations
Hypertension
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