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PHKA1 antisense RNA 1 (PHKA1-AS1)
- Target
- PHKA1-AS1
- Molecular classification
- Long noncoding RNA (lncRNA), Natural antisense transcript
01
Overview
PHKA1 antisense RNA 1 (PHKA1-AS1) is a long noncoding RNA (lncRNA) arising as a natural antisense transcript to the *PHKA1* gene. It consists of 599 base pairs and lacks protein-coding potential. PHKA1-AS1 is upregulated in non-small cell lung cancer (NSCLC), where increased N6-methyladenosine (m6A) modification stabilizes it. In cancer, PHKA1-AS1 promotes cell proliferation, migration, and metastasis by binding to actinin alpha 4 (ACTN4)—an oncogenic protein—and suppressing its ubiquitin-mediated degradation, thus enhancing ACTN4 protein stability. Inhibition of PHKA1-AS1 reverses these pro-tumorigenic effects. PHKA1-AS1 is studied as a potential biomarker of tumor progression, particularly in NSCLC, but is not itself a therapeutic target, receptor, enzyme, or transporter[1][5][6].
- Other names
- PHKA1 antisense RNA 1 (non-protein coding)PHKA1-AS1
02
Biological functions
Post-transcriptional regulationRegulation of protein stabilityGene expression regulationPromotion of cell proliferationPromotion of metastasis
03
Disease associations
Cancer (specifically non-small cell lung cancer)Tumor progressionMetastasis
04
Biomarkers
Potential biomarker for non-small cell lung cancer (expression level correlates with NSCLC progression)
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