Phlegm resolution via multi-target modulation in TCM theory

Phlegm resolution via multi-target modulation in TCM theory" is not a discrete molecular entity, but a *holistic therapeutic principle* or method in traditional Chinese medicine. It encompasses strategies and combinations of herbs (such as Er Chen Tang and Liu Junzi Decoction), acupuncture, and other interventions designed to resolve “phlegm,” understood in TCM as a pathological substance related to imbalances of Spleen, Lung, and dampness. The “multi-target modulation” refers to TCM’s concurrent effects on immune, inflammatory, metabolic, and fluid-regulation pathways. In modern research, this strategy is reported to act through broad anti-inflammatory effects (e.g., via NF-κB inhibition), modulation of mucin secretion, regulation of immune function, and improvement of respiratory system balance. However, this concept is not a recognized molecular or pharmacological target in current biomedical science, and should not be classified as such[1][2][3][4][7][8][9].

Other names

Phlegm-resolving method in TCMPhlegm-dampness resolutionPhlegm transformation strategyTCM phlegm elimination

Not applicable at a molecular level; in systems biology/TCM, includes modulation of inflammation (e.g., NF-κB pathway), immune support, regulation of mucus, strengthening Spleen/lung, Qi regulation