Phleum pratense pollen major allergen (typically referring to Phl p 1 or Phl p 5) (Phl p 1 or Phl p 5 (according to specific allergen context))

Phleum pratense pollen major allergens, most notably Phl p 1 and Phl p 5, are proteins that act as potent triggers of IgE-mediated allergic reactions in sensitized individuals, causing conditions such as allergic rhinitis and asthma[1][3][5]. Phl p 1 is a non-enzymatic major allergen, while Phl p 5 possesses ribonuclease activity and contributes to host-pathogen interactions[6]. Both are widely distributed in temperate climates, resulting in a global burden of grass pollen allergy, and both serve as main targets in allergen immunotherapy and allergy diagnostics. The allergens induce mast cell and basophil degranulation upon cross-linking of IgE, and measurement of patient-specific IgE to these proteins allows for precise diagnosis and personalized treatment strategies[1][3][5][6][7].

Other names

Timothy grass major allergenGrass pollen major allergen (timothy grass)Phl p 1Phl p 5Timothy grass pollen allergenCommon timothy major allergen

IgE binding: Allergens bind patient IgE and cross-link on mast cells/basophils, triggering histamine release and allergic inflammation Immunotherapy: Modifies immune response by repeated low-dose exposure, promoting tolerance to allergen (Phl p 1 or Phl p 5)