Target intelligence / Profile preview

Phorbol-12-myristate-13-acetate-induced protein 1 (Noxa)

Target: Noxa
Molecular classification: BH3-only protein, BCL-2 family protein

Overview

PMAIP1, also known as Noxa, is a pro-apoptotic protein belonging to the BH3-only subfamily of the BCL-2 family. It promotes apoptosis by activating caspases and inducing mitochondrial membrane changes. Its expression is regulated by p53 and it plays a role in p53-mediated apoptotic pathways. Noxa interacts with anti-apoptotic BCL-2 family proteins like MCL-1 to neutralize their function, thereby promoting cell death.

Other names: NoxaAPR

Mechanism of action

Induction of apoptosis through neutralization of anti-apoptotic BCL-2 family members, leading to mitochondrial outer membrane permeabilization and caspase activation.

Biological functions

ApoptosisCell deathTumor suppression

Disease associations

CancerLeukemiaMantle Cell Lymphoma

Safety considerations

Potential for off-target effects on other cell types.Induction of excessive apoptosis leading to tissue damage.

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