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Phosphatase and Tensin Homolog (PTEN)
- Target
- PTEN
- Molecular classification
- Phosphatase, Tumor Suppressor
01
Overview
PTEN is a tumor suppressor gene encoding a dual-specificity phosphatase that negatively regulates the PI3K/AKT pathway by dephosphorylating PIP3 to PIP2. It plays a crucial role in controlling cell proliferation, survival, metabolism, migration, adhesion, angiogenesis, genetic stability, and DNA repair. Loss or mutation of PTEN is common in many cancers, leading to unchecked PI3K/AKT activity and tumorigenesis.
- Other names
- MMAC1TEP1
02
Mechanism of action
PTEN dephosphorylates PIP3 to PIP2, inhibiting AKT activation. Drugs may aim to restore PTEN function or indirectly modulate the pathway.
03
Biological functions
Regulation of PI3K/AKT pathwayCell cycle regulationApoptosis regulationCell migrationCell adhesionAngiogenesis regulationDNA damage responseDNA repair
04
Disease associations
CancerBannayan-Riley-Ruvalcaba syndrome
05
Safety considerations
Restoring PTEN activity could have broad effects on cellular signaling.Potential for off-target effects.
06
Interacting drugs
PTEN inhibitors (in development)
07
Biomarkers
PTEN expression levelPTEN mutation statusPIP3 levelsAKT phosphorylation status
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