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Target intelligence / Profile preview
Phosphatase and tensin homolog deleted on chromosome ten (PTEN)
- Target
- PTEN
- Molecular classification
- Phosphatase, Tumor suppressor
01
Overview
PTEN is a dual-specificity phosphatase that functions as a tumor suppressor by dephosphorylating PIP3, thus antagonizing the PI3K/AKT signaling pathway. Loss or mutation of PTEN leads to uncontrolled cell proliferation and tumorigenesis. It also plays a role in DNA repair and genomic stability. PTEN is a therapeutic target in cancers with deficient PTEN function.
02
Mechanism of action
Inhibition of PI3K/AKT/mTOR signaling
03
Biological functions
Cell cycle regulationApoptosisCell migrationCell adhesionAngiogenesisGenomic stabilityDNA damage responseMetabolic regulation
04
Disease associations
CancerCowden syndromeBannayan-Riley-Ruvalcaba syndromePTEN hamartoma tumor syndrome (PHTS)
05
Safety considerations
Therapeutic strategies targeting PI3K/AKT/mTOR pathway may have broad effects due to the pathway's involvement in multiple cellular processes.
06
Biomarkers
PTEN expression levelPTEN mutation status
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