Phosphatase and tensin homolog pseudogene (PTENP1)

The phosphatase and tensin homolog pseudogene (commonly referred to as PTENP1) is a non-protein-coding RNA gene related to the canonical PTEN tumor suppressor gene. While PTENP1 shares high sequence similarity with PTEN, it does not produce a functional phosphatase enzyme. PTENP1 and other PTEN pseudogenes can act post-transcriptionally to regulate the expression and stability of PTEN mRNA by serving as competing endogenous RNAs, thus indirectly influencing PTEN protein levels and thereby tumor biology. However, PTENP1 itself is not an established therapeutic target because it does not encode a protein product[2]. Only the canonical PTEN (phosphatase and tensin homolog) exhibits enzymatic activity with critical roles in *PI3K/AKT/mTOR signaling*, *cell proliferation*, *growth*, and *tumor suppression*[1][2][3][4][5]. Important note: The canonical target in most research and clinical contexts is Phosphatase and tensin homolog (PTEN), not the pseudogene. PTEN is a therapeutic target, tumor suppressor, and lipid/protein phosphatase involved in cell signaling, metabolism, and cancer[1][2][3][4][5]. The pseudogene (ENSG00000261882, PTENP1) is not directly targeted for therapy and does not produce an active protein[2]. There appears to be a nomenclature error or copy-paste mistake in the query as written (repetition of "phosphatase and tensin homolog" and ambiguous reference to a pseudogene).

Other names

PTENP1phosphatase and tensin homolog pseudogene 1PTEN pseudogene