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Target intelligence / Profile preview
Phosphatase of Regenerating Liver 3 (PRL-3)
- Target
- PRL-3
- Molecular classification
- Enzyme, Dual specificity phosphatases (DSPs), Protein tyrosine phosphatase (PTP)
01
Overview
Phosphatase of regenerating liver 3 (PRL-3), also known as PTP4A3, is a dual-specificity phosphatase implicated in tumor metastasis, proliferation, and angiogenesis. It is often overexpressed in metastatic cancers, making it a potential therapeutic target. PRL-3 modulates several signaling pathways, including PI3K/Akt, p38 MAPK, WNT/β-catenin, and Src kinase. Post-translational modifications like prenylation are crucial for its membrane localization and activity.
- Other names
- PTP4A3
02
Mechanism of action
Inhibition of PRL-3 phosphatase activity
03
Biological functions
Cell cycle progressionCell proliferationCell migrationCell invasionAngiogenesisAutophagy
04
Disease associations
CancerMetastasis
05
Safety considerations
Potential for off-target effects due to phosphatase activity
06
Biomarkers
PRL-3 overexpression in tumor tissue
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