Phosphatidate phosphatase LPIN3 (LPIN3)

Phosphatidate phosphatase LPIN3 (abbreviated as LPIN3) is a magnesium-dependent enzyme of the lipin protein family that catalyzes the conversion of phosphatidic acid to diacylglycerol, a key step in the biosynthesis of triglycerides and phospholipids[1][2][3]. LPIN3, like other lipin family members, acts as a regulator of fatty acid and glycerolipid metabolism. It contains conserved domains for enzymatic (phosphatidate phosphatase) and transcriptional co-activator activities, and may form oligomers with other lipins. LPIN3 is mainly expressed at low levels, with highest expression in human small intestine and bone[3]. Although less is known about the physiological role of LPIN3 compared to other lipins, variants in LPIN3 have been associated with metabolic traits, including fasting glucose levels, through human genetic studies[3]. Its deficiency or dysfunction may contribute to lipid-storage diseases, with most data so far implicating metabolic disorders[1][3]. At present, there are no known direct drugs, biomarker uses, or major safety concerns specifically associated with LPIN3 as a target.

Other names

Lipin 3Lipin-3Lipin-3-likeLPIN3LIPN3LSMP2dJ620E11.2Phosphatidate phosphatase LPIN3