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Phosphatidylethanolamine (None)

Target: None
Molecular classification: Glycerophospholipid

Overview

Phosphatidylethanolamine (PE) is a class of glycerophospholipids and the second most abundant phospholipid in eukaryotic cells. It is a major component of cell membranes, particularly enriched in the inner leaflet of plasma membranes and mitochondrial membranes. PE plays crucial roles in maintaining membrane structure, fluidity, and curvature, which are essential for various cellular processes like vesicle trafficking, protein integration, and autophagy. Alterations in PE metabolism have been linked to several diseases, including neurodegenerative disorders, liver disease, and cardiovascular conditions.

Mechanism of action

N/A

Biological functions

Maintains structural integrity and fluidity of cell membranesPrecursor for other lipids such as phosphatidylcholineSubstrate for posttranslational modifications including protein lipidationMembrane fusionProtein integrationAutophagyVesicle traffickingMitochondrial biogenesis

Disease associations

Neurodegenerative diseasesNonalcoholic liver diseaseCardiovascular disease (ischemia)Cancer (related to PEBP4 overexpression)Infection (related to pathogen virulence)

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