Phosphatidylethanolamine binding protein 1 pseudogene 3 (PEBP1P3)

Phosphatidylethanolamine binding protein 1 pseudogene 3 (PEBP1P3) is a pseudogene in the human genome. It is annotated as a natural antisense transcript (NAT) located on the opposite strand of CD45 intron 2 and produces a noncoding RNA. PEBP1P3 RNA is primarily expressed as a nuclear-localized transcript, especially in testis, blood, and lymphoid tissues. Its expression correlates with CD45 RNA levels, and functional studies indicate it regulates the alternative splicing of CD45 pre-mRNA via modifying local DNA methylation and histone marks. PEBP1P3 does not encode a functional protein and is not itself a traditional therapeutic target such as a receptor, enzyme, or transporter. Altered expression or function of PEBP1P3 may impact immune cell biology by modulating CD45 isoform expression, but no direct therapeutic targeting or drug interaction is known. Key notes: - This target is a pseudogene-derived noncoding RNA, not a functional protein. - It is occasionally referenced in the context of transcriptional/epigenetic regulation, not as a drug or therapeutic target. - Being a pseudogene, PEBP1P3 is not considered a direct therapeutic target. - No evidence for drug interactions, biomarker use, or safety relevance exists. If you need information on the functional PEBP1 protein (Raf Kinase Inhibitor Protein, RKIP), which is a protein and a recognized regulator in several signaling pathways, that is a distinct gene (PEBP1, not PEBP1P3).

Not applicable (not a protein-coding target, not targeted by drugs)