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Target intelligence / Profile preview
Phosphatidylethanolamine N-methyltransferase (PEMT)
- Target
- PEMT
- Molecular classification
- Enzyme, Transferase, Methyltransferase
01
Overview
Phosphatidylethanolamine N-methyltransferase (PEMT) is an enzyme that catalyzes the methylation of phosphatidylethanolamine (PE) to form phosphatidylcholine (PC). It is primarily localized in the endoplasmic reticulum and mitochondria-associated membranes, especially in liver cells. PEMT plays a critical role in maintaining membrane integrity, regulating VLDL secretion, and contributing to choline homeostasis. Deficiency or dysregulation of PEMT can lead to various metabolic disturbances, including steatohepatitis and increased susceptibility to NAFLD. PEMT activity is regulated by substrate/product availability, hormonal factors, and genetic variants.
- Other names
- LMTasephosphatidylethanolamine methyltransferasephosphatidylethanolamine-N-methylasephosphatidylethanolamine-S-adenosylmethionine-methyltransferase
02
Mechanism of action
Inhibiting or modulating PEMT activity can alter PC/PE ratios, VLDL secretion, and choline metabolism.
03
Biological functions
Membrane biogenesisVLDL secretionCholine homeostasisOne-carbon metabolism
04
Disease associations
Nonalcoholic fatty liver disease (NAFLD)SteatohepatitisCardiovascular diseasesNeural tube defectsType II diabetes mellitusAlzheimer’s diseaseCancer
05
Safety considerations
Altering PEMT activity can disrupt lipid metabolism and potentially lead to liver dysfunction or other metabolic disorders.
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