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Target intelligence / Profile preview
Phosphatidylinositide 3-Kinase (None)
- Target
- None
- Molecular classification
- Enzyme, Kinase, Lipid Kinase
01
Overview
Phosphatidylinositide 3-kinase (PI3K) is a family of intracellular enzymes that play a central role in cellular signaling, regulating cell growth, proliferation, differentiation, motility, survival, metabolism, and intracellular trafficking. Dysregulation of PI3K activity is implicated in various diseases including cancer and immune disorders.
- Other names
- Phosphoinositide 3-KinasePI3K
02
Mechanism of action
Phosphorylates phosphatidylinositol lipids, leading to the production of PIP3 and activation of downstream signaling pathways like AKT/protein kinase B.
03
Biological functions
Cell growthCell proliferationCell differentiationCell motilityCell survivalMetabolismIntracellular traffickingSignal transductionImmune responseApoptosis inhibitionCytoskeletal rearrangement
04
Disease associations
CancerImmune disordersInflammatory disorders
05
Safety considerations
Efficacy/toxicity depends on specific isoform targeting.Varied tissue distribution of isoforms
06
Interacting drugs
Idelalisib
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