Target intelligence / Profile preview

Phosphatidylinositol 3-kinase–Protein Kinase B pathway (PI3K/AKT pathway)

Target: PI3K/AKT pathway
Molecular classification: Signaling pathway

Overview

The PI3K/AKT pathway, also known as the phosphatidylinositol 3-kinase–protein kinase B pathway, is a critical intracellular signaling cascade that regulates fundamental cellular processes such as metabolism, growth, proliferation, survival, angiogenesis, and cell cycle progression. It is activated by various extracellular signals including growth factors and hormones.

Other names: PI3K/Akt/mTOR pathway

Biological functions

Metabolism regulationGrowth regulationCell proliferationCell survivalAngiogenesisCell cycle progression

Disease associations

CancerDiabetesNeurological disordersImmunological disorders

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