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Target intelligence / Profile preview
Phosphatidylinositol 3-Kinase Beta (PI3Kβ)
- Target
- PI3Kβ
- Molecular classification
- Enzyme, Lipid Kinase, Phosphoinositide 3-Kinase, Class IA Phosphoinositide 3-Kinase
01
Overview
Phosphatidylinositol 3-kinase beta (PI3Kβ) is a Class IA PI3K, a lipid kinase that phosphorylates phosphoinositides. It is a heterodimer composed of a catalytic subunit (p110β) and a regulatory subunit (p85, p55, or p50). PI3Kβ integrates signals from receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs), and small GTPases. It plays critical roles in various physiological processes, including spermatogenesis, macrophage function, osteoclast development, neutrophil function, and platelet activation. Dysregulation of PI3Kβ is linked to cancer, thrombosis, male infertility, and Fragile X syndrome. Selective inhibitors are under development as potential therapeutics.
- Other names
- PIK3CBp110β
02
Mechanism of action
Selective inhibition of PI3Kβ
03
Biological functions
Phosphorylation of phosphoinositidesCell metabolismCell survivalCell proliferationCell motilitySpermatogenesisMacrophage functionOsteoclast developmentBone homeostasisNeutrophil functionPlatelet activationThrombosis regulationSignal transduction
04
Disease associations
CancerPTEN-deficient tumorsThrombosisMale infertilityFragile X syndrome
05
Safety considerations
Potential toxicity compared to pan-class I inhibitorsOff-target effects
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