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Target intelligence / Profile preview
Phosphatidylinositol 3-Kinase Beta Catalytic Subunit (PI3Kβ)
- Target
- PI3Kβ
- Molecular classification
- Enzyme, Kinase, Lipid Kinase, Phosphoinositide 3-Kinase
01
Overview
Phosphatidylinositol 3-kinase beta (PI3Kβ) is a class IA PI3K catalytic subunit, forming a heterodimer with regulatory subunits. It integrates signals from receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs), and small GTPases to regulate cell growth, proliferation, metabolism, and immune functions. PI3Kβ is implicated in cancer progression, making it a therapeutic target, but its inhibition can lead to immune-related side effects.
- Other names
- PI3KBETAp110betaPIK3CB
02
Mechanism of action
Inhibition of PI3Kβ kinase activity, blocking downstream signaling.
03
Biological functions
Signal transductionCell growthCell proliferationCell metabolismSpermatogenesisImmune responseBone homeostasisMacrophage functionNeutrophil activityPlatelet function
04
Disease associations
CancerCancer progressionCancer metastasis
05
Safety considerations
Immune suppressionOn-target toxicities due to broad role of PI3K isoforms
06
Interacting drugs
PI3K inhibitors (selective and pan-PI3K)
1 more in the full profile.
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