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Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)
- Target
- PIK3C3
- Molecular classification
- Enzyme, Lipid kinase, Phosphoinositide 3-kinase (Class III)
01
Overview
Phosphatidylinositol 3-kinase catalytic subunit type 3 (VPS34, PIK3C3) is a lipid kinase belonging to Class III PI3Ks. It catalyzes the phosphorylation of phosphatidylinositol (PI) to generate phosphatidylinositol 3-phosphate (PI3P), which is essential for membrane trafficking pathways, especially those regulating autophagy and endosomal sorting. VPS34 is ubiquitously expressed and plays a unique role compared to Class I and II PI3Ks. It is emerging as a therapeutic target in cancer and other diseases where autophagy, vesicle trafficking, and cellular metabolism are dysregulated.
- Other names
- VPS34PIK3C3Class III phosphoinositide 3-kinaseHuman VPS34
02
Mechanism of action
Inhibition of autophagy by blocking generation of phosphatidylinositol 3-phosphate (PI3P), a product of VPS34 kinase activity and essential for early steps in autophagosome formation. Alteration of vesicle trafficking within the cell.
03
Biological functions
Autophagy regulationEndosomal trafficking/vesicle traffickingMacrophage phagocytosisCellular lipid signaling
04
Disease associations
Cancer (emerging evidence for its involvement in cancer cell survival, autophagy, and metabolism)Neurodegenerative disease (through effects on autophagy)Infection (involved in viral life cycles and immune response regulation)
05
Safety considerations
Disruption of autophagy may impair normal cellular homeostasisPotential for toxicity in tissues highly dependent on autophagy (such as liver or nervous system)Broad PI3K inhibition may affect multiple signaling pathways, causing off-target effects
06
Interacting drugs
VPS34-selective inhibitors (e.g., specific research compounds described in literature)
1 more in the full profile.
07
Biomarkers
PI3P levels (may be used in research/monitoring efficacy of VPS34 inhibition)Autophagy markers (such as LC3-II, p62/SQSTM1 accumulation)
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