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Target intelligence / Profile preview
Phosphatidylinositol 3-kinase delta (PI3Kδ)
- Target
- PI3Kδ
- Molecular classification
- Enzyme, Lipid kinase, Phosphoinositide 3-kinase
01
Overview
Phosphatidylinositol 3-kinase delta (PI3Kδ) is a lipid kinase and a member of the class I phosphoinositide 3-kinases. It functions as a heterodimer composed of a catalytic subunit (p110δ) and a regulatory subunit (typically p85α or p85β). PI3Kδ is highly expressed in leukocytes and plays a central role in immune cell signaling, particularly in B cells and T cells, mediating survival, migration, and activation. Dysregulation of PI3Kδ is associated with immunodeficiency syndromes (e.g., APDS) and hematological malignancies, making it a validated therapeutic target. Selective inhibitors, such as idelalisib, have been developed for the treatment of certain blood cancers.
- Other names
- p110δPIK3CD
02
Mechanism of action
Selective inhibition of PI3Kδ, blocking downstream signaling pathways such as AKT/mTOR.
03
Biological functions
Immune cell signalingB cell activationT cell activationSignal transductionCell survivalCell migrationPhosphoinositide phosphorylation
04
Disease associations
Activated Phosphoinositide 3-Kinase Delta Syndrome (APDS)ImmunodeficiencyRecurrent InfectionsLymphoproliferationAutoimmunityHematological malignanciesLeukemiaLymphomaCancer
05
Safety considerations
Potential for immune-related adverse events due to the role of PI3Kδ in immune regulation.
06
Interacting drugs
Idelalisib
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