Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Phosphatidylinositol 3-kinase delta catalytic subunit (PI3Kδ)
- Target
- PI3Kδ
- Molecular classification
- Lipid Kinase, Enzyme, PI3K, Class I PI3K
01
Overview
PI3Kδ/p110δ is a leukocyte-enriched lipid kinase crucial for adaptive immunity. Its dysregulation leads to immunodeficiencies or contributes to cancer pathogenesis. Selective pharmacological targeting exploits structural features unique among class I isoforms—enabling effective therapies with reduced systemic toxicity compared to non-selective inhibition.
- Other names
- p110δPIK3CD
02
Mechanism of action
Selective inhibition of PI3Kδ
03
Biological functions
Signal transductionImmune cell developmentImmune cell functionCell proliferationCell survivalCell differentiationCell migrationPhosphoinositide phosphorylation
04
Disease associations
ImmunodeficiencyCancerHematological malignanciesLymphoproliferative disorders
05
Safety considerations
Off-target effects (though less than pan-PI3K inhibitors)Systemic toxicity
06
Interacting drugs
Idelalisib
Beyond the preview
Go deeper on Phosphatidylinositol 3-kinase delta catalytic subunit (PI3Kδ).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Phosphatidylinositol 3-kinase delta catalytic subunit (PI3Kδ).