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Target intelligence / Profile preview
Phosphatidylinositol 3-Kinase Family (PI3K)
- Target
- PI3K
- Molecular classification
- Enzyme, Kinase, Lipid Kinase
01
Overview
The Phosphatidylinositol 3-Kinase (PI3K) family is a group of intracellular enzymes that phosphorylate phosphoinositides, playing crucial roles in cell growth, proliferation, survival, and metabolism. They are divided into three classes (I, II, and III) based on structure and substrate specificity. Dysregulation of PI3K signaling is frequently observed in cancer, making it an attractive therapeutic target. Class I PI3Ks are the most studied due to their central role in cancer biology and immune regulation. Several small molecule inhibitors targeting specific isoforms have been developed.
- Other names
- Phosphoinositide 3-KinasePI3 Kinase
02
Mechanism of action
Inhibition of PI3K enzymatic activity, blocking downstream signaling pathways.
03
Biological functions
Cell growthCell proliferationCell differentiationCell motilityCell survivalIntracellular traffickingCell cycle progressionApoptosis inhibitionCellular metabolismAngiogenesisSignal transduction
04
Disease associations
CancerDiabetesImmune disorders
05
Safety considerations
HyperglycemiaImmune-related adverse events
06
Interacting drugs
PI3K inhibitors
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