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Target intelligence / Profile preview
Phosphatidylinositol 3-kinase gamma catalytic subunit (PI3Kγ)
- Target
- PI3Kγ
- Molecular classification
- Enzyme, Kinase, Phosphoinositide 3-Kinase, Lipid Kinase
01
Overview
Phosphatidylinositol 3-kinase gamma (PI3Kγ) is a lipid kinase that phosphorylates phosphatidylinositol(4,5)-bisphosphate [PI(4,5)P₂] to generate phosphatidylinositol(3,4,5)-trisphosphate [PI(3,4,5)P₃]. It plays a crucial role in immune cell function, particularly in myeloid cells, and is involved in chemotaxis, cytokine release, and inflammatory responses. PI3Kγ is activated downstream of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases. It is considered a drug target for cancer therapy and immune disorders.
- Other names
- p110γPIK3CGPhosphoinositide-3-Kinase Catalytic Subunit Gamma
02
Mechanism of action
Inhibition of PI3Kγ catalytic activity.
03
Biological functions
Signal transductionImmune responseCell migrationChemotaxisCytokine releaseRegulation of inflammatory responsesRegulation of reactive oxygen species generationCardiac contractility
04
Disease associations
CancerInflammationImmune disordersCardiovascular disease
05
Safety considerations
Potential for off-target effects due to kinase family similarity.Immune-related adverse events.
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