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Target intelligence / Profile preview
Phosphatidylinositol 3-Kinase Gamma Subunit (PI3Kγ)
- Target
- PI3Kγ
- Molecular classification
- Lipid Kinase, Phosphoinositide 3-Kinase (PI3K), Enzyme
01
Overview
Phosphatidylinositol 3-kinase gamma (PI3Kγ) is a lipid kinase and the only member of class IB PI3Ks. It plays a crucial role in immune cell signaling, regulating chemotaxis, cytokine release, and ROS generation. PI3Kγ exists as a heterodimer, composed of a catalytic subunit (p110γ) and a regulatory subunit (p101 or p84/p87). It is activated downstream of GPCRs and other receptor types, making it a key therapeutic target for inflammatory diseases and cancer.
- Other names
- PI3K gammaPIK3CGp110γp101/p110γ complexp84/p110γ complexp87/p110γ complex
02
Mechanism of action
PI3Kγ phosphorylates phosphatidylinositol 4,5-bisphosphate [PI(4,5)P₂] to generate phosphatidylinositol 3,4,5-trisphosphate [PIP₃], a key second messenger in cell signaling. Inhibitors block this phosphorylation.
03
Biological functions
Signal transductionImmune responseCell migrationCytokine productionReactive oxygen species (ROS) generationRegulation of cardiac electrophysiology
04
Disease associations
Inflammatory diseasesCancerAutoimmunityCardiovascular disease
05
Safety considerations
Potential for immunosuppressionOff-target effects due to PI3K family homology
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