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Target intelligence / Profile preview
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
- Target
- PIK3R1
- Molecular classification
- Enzyme, Regulatory subunit, SH2 domain-containing protein
01
Overview
Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme encoded by the PIK3R1 gene in humans. It serves as a critical regulatory component of phosphatidylinositol 3-kinase (PI3K), a family of lipid kinases that play essential roles in numerous cellular processes. It regulates the activity of the PI3K enzyme, stabilizes the catalytic subunit, recruits PI3K to the plasma membrane, and mediates the association of the catalytic unit to the plasma membrane. Mutations in PIK3R1 are implicated in cancer, SHORT syndrome, and insulin resistance. It is a promising drug target in cancer and immune disorders.
- Other names
- p85 alphap85αp55 alphap55αp50 alphap50α
02
Mechanism of action
Inhibiting PI3K activity
03
Biological functions
Signal transductionRegulation of PI3K activityInsulin signalingGrowth factor signalingCell survivalCell proliferationIntegrin signalingER stress response
04
Disease associations
CancerSHORT syndromeInsulin resistance
05
Safety considerations
Potential for off-target effects due to the broad role of PI3K in cellular signalingDevelopment of resistance to PI3K inhibitors
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