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Target intelligence / Profile preview
Phosphatidylinositol 3-kinase regulatory subunit beta (p85β)
- Target
- p85β
- Molecular classification
- Regulatory subunit, PI3K subunit
01
Overview
The Phosphatidylinositol 3-kinase regulatory subunit beta (p85β) is a regulatory component of the PI3K enzyme, playing a crucial role in cell growth, proliferation, differentiation, and survival. It stabilizes and inhibits the catalytic subunit of PI3K and is involved in the PI3K/AKT signaling pathway. Elevated expression of p85β has been linked to tumor progression. It participates in B cell differentiation, the immune response, and intracellular glucose homeostasis. Mutations in p85β have been associated with megalencephaly syndromes.
02
Mechanism of action
Modulation of PI3K signaling pathways
03
Biological functions
Cell signalingCell growthCell proliferationCell differentiationCell survivalImmune responseMetabolic regulationStabilizing and inhibiting the catalytic subunit of PI3KIntracellular glucose homeostasis
04
Disease associations
CancerMegalencephaly syndromes
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