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Phosphatidylinositol 4,5-bisphosphate 3-kinase beta (PI3Kβ)
- Target
- PI3Kβ
- Molecular classification
- Enzyme, Lipid Kinase, Phosphoinositide Kinase, PI3K, Protein Kinase
01
Overview
Phosphatidylinositol 4,5-bisphosphate 3-kinase beta (PI3Kβ) is an isoform of the class IA phosphoinositide 3-kinases (PI3Ks), a family of lipid kinases that play central roles in cellular signaling. PI3Kβ specifically catalyzes the phosphorylation of phosphatidylinositol-4,5-bisphosphate (PIP2) to generate phosphatidylinositol-3,4,5-trisphosphate (PIP3), a second messenger that regulates diverse cellular processes including growth, proliferation, survival, metabolism, and motility. It is a heterodimer composed of a regulatory subunit (often p85α or its variants) and a catalytic subunit (p110β). PI3Kβ has both kinase-dependent and kinase-independent functions, most notably in DNA replication and cell cycle progression in addition to its role in canonical PI3K/AKT/mTOR signaling.
- Other names
- PI3KBETAPI3K betap110βPhosphoinositide 3-kinase beta
02
Mechanism of action
Inhibition of PI3Kβ activity
03
Biological functions
Signal transductionCell cycleCell proliferationCell growthMetabolismDNA replicationCell survival
04
Disease associations
CancerTumorigenesisMetabolic disorders
05
Safety considerations
Potential for off-target effects due to homology with other PI3K isoformsDevelopment of resistance
06
Interacting drugs
GSK2636771
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