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Target intelligence / Profile preview
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3Kβ)
- Target
- PI3Kβ
- Molecular classification
- Enzyme, Lipid kinase, Class IA Phosphoinositide 3-Kinase
01
Overview
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3Kβ or p110β) is a lipid kinase that phosphorylates PI(4,5)P2 to generate PI(3,4,5)P3, a key secondary messenger involved in cell signaling pathways regulating cell growth, proliferation, metabolism, survival, and motility. It belongs to the class IA PI3K family and is implicated in various diseases, including cancer and metabolic disorders.
- Other names
- p110βPIK3CB
02
Mechanism of action
PI3Kβ inhibitor
03
Biological functions
Signal transductionCell growthCell proliferationMetabolismCell survivalCell motilityPhosphorylation of phosphatidylinositides
04
Disease associations
CancerMetabolic Disorders
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