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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (p110δ)
- Target
- p110δ
- Molecular classification
- Enzyme, Class IA Phosphoinositide (PI) kinases
01
Overview
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (p110δ) is a lipid kinase primarily expressed in leukocytes. It is a member of the Class IA PI3K family and plays a crucial role in immune cell signaling, including T cell, B cell, mast cell, and neutrophil activation. By phosphorylating phosphatidylinositol (PI) and its derivatives to generate phosphatidylinositol-(3,4,5)-trisphosphate (PIP3), it regulates various cellular processes such as cell proliferation, survival, and migration. Due to its involvement in immune regulation and its dysregulation in certain cancers, p110δ is a target for therapeutic intervention, with selective inhibitors like idelalisib used in the treatment of hematologic malignancies.
- Other names
- PI3KδPhosphoinositide 3-kinase delta isoformPIK3CD
02
Mechanism of action
Inhibition of PI3Kδ
03
Biological functions
Signal transductionImmune responseT cell activationB cell activationMast cell chemotaxisNeutrophil chemotaxisInflammatory responseRegulation of actin cytoskeleton dynamicsProtein phosphorylationAdaptive immune responseInnate immune responsePositive regulation of gene expression
04
Disease associations
CancerImmunodeficiencyAutoimmune diseasesInflammation
05
Safety considerations
InfectionsAutoimmune complications
06
Interacting drugs
Idelalisib
2 more in the full profile.
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