Target intelligence / Profile preview

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)

Target: PIK3CG
Molecular classification: Enzyme, Kinase, PI3K

Overview

PIK3CG encodes a protein belonging to the pi3/pi4-kinase family. It phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring, playing a crucial role in modulating extracellular signals, including those involved in cell-cell adhesion and immune responses. It is implicated in inflammatory conditions and cancers, making it a potential therapeutic target.

Mechanism of action

PIK3CG inhibition

Biological functions

Signal transductionCell proliferationCell survivalImmune responseCell-cell adhesion

Disease associations

CancerInflammationRheumatoid arthritisAtherosclerosisAcute Myeloid Leukemia (AML)

Interacting drugs

IPI-549

1 more in the full profile.

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