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Target intelligence / Profile preview
Phosphatidylinositol 4,5-bisphosphate 3-kinase gamma (PI3Kγ)
- Target
- PI3Kγ
- Molecular classification
- Enzyme, Lipid Kinase, Phosphoinositide 3-Kinase (PI3K)
01
Overview
Phosphatidylinositol 4,5-bisphosphate 3-kinase gamma (PI3Kγ) is a lipid kinase that phosphorylates phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P₂] to generate phosphatidylinositol (3,4,5)-trisphosphate [PIP₃]. PIP₃ acts as a second messenger involved in cell growth, survival, motility, and immune responses. PI3Kγ integrates signals from G-protein coupled receptors and is a potential therapeutic target in cancer, particularly acute myeloid leukemia, and inflammatory respiratory diseases.
- Other names
- PIK3CG
02
Mechanism of action
Inhibition of PI3Kγ kinase activity, blocking downstream signaling pathways.
03
Biological functions
Signal transductionImmune responseCellular motilityCell growthCell survivalIntracellular trafficking
04
Disease associations
CancerAcute Myeloid Leukemia (AML)Respiratory diseasesAsthmaPulmonary fibrosisInflammation
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