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Target intelligence / Profile preview
Phosphatidylinositol-4-kinase beta (PI4KB)
- Target
- PI4KB
- Molecular classification
- Enzyme, Lipid Kinase, Kinase
01
Overview
Phosphatidylinositol‑4‑kinase beta (PI4KB) is a key enzyme involved in the phosphorylation of phosphatidylinositol (PI) to generate phosphatidylinositol 4-phosphate (PI4P), an essential lipid signaling molecule that regulates various cellular processes, particularly membrane trafficking and organelle identity. It is crucial for defining Golgi and trans-Golgi network membranes, regulating vesicular trafficking from the Golgi to plasma membrane and maintaining structural integrity of the Golgi complex. Many positive-sense single-stranded RNA viruses hijack human PI4KB to create specialized membranous webs enriched in PI4P, which serve as platforms for viral replication. Additionally, Plasmodium falciparum's homologous enzyme is targeted by antimalarial imidopyrazines.
- Other names
- PI4K beta
02
Mechanism of action
Inhibition of PI4KB activity
03
Biological functions
Phosphatidylinositol phosphorylationVesicular traffickingOrganelle identityMembrane transport
04
Disease associations
Viral replicationMalaria
05
Interacting drugs
Picornavirus inhibitors
1 more in the full profile.
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