Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma (PI3K-C2γ)

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma (PI3K-C2γ) is a class II member of the PI3K family, which phosphorylates the 3-position of the inositol ring in phosphoinositides. The enzyme contains a C-terminal C2 domain—acting as a calcium-dependent phospholipid-binding motif—alongside a lipid kinase catalytic domain. PI3K-C2γ is involved in lipid signaling that regulates cellular processes such as intracellular protein trafficking, cell proliferation, and survival. Its specific biological functions remain incompletely characterized, but gene expression perturbations and pathway analyses suggest roles in cancer biology and potentially other diseases[4][8][2]. PI3K-C2γ differs from the more commonly studied PI3K isoforms (e.g., class I p110α, p110β, p110γ) in structure and regulatory mechanisms; unlike class I, it lacks a regulatory subunit and has unique N-terminal extensions[2]. No selective drugs or clinical biomarkers exist for this target at present.

Other names

PIK3C2GPI3K-C2-gammaPI3K-C2GAMMAphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma

Lipid kinase inhibition (for hypothetical or research-stage modulators); general PI3K inhibition mechanism could apply if selective agents are developed