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Target intelligence / Profile preview
Phosphatidylinositol 4-phosphate 3-kinase regulatory subunit alpha (PIK3R1)
- Target
- PIK3R1
- Molecular classification
- Adaptor protein, Regulatory subunit, SH2 domain containing protein, SH3 domain containing protein
01
Overview
Phosphatidylinositol 4-phosphate 3-kinase regulatory subunit alpha (PIK3R1/p85α) is an essential regulator/adaptor for class IA PI(4)P kinases central to many critical cellular processes—especially those governing metabolism and growth factor responses—with major implications for cancer biology and metabolic disease when mutated or dysregulated.
- Other names
- p85αp55αp50α
02
Mechanism of action
Inhibition of PI3K signaling
03
Biological functions
Signal transductionRegulation of cell growthRegulation of cell proliferationRegulation of cell survivalRegulation of cell migrationRegulation of metabolismRegulation of protein synthesisInsulin signalingImmune modulationRegulation of actin cytoskeleton dynamics
04
Disease associations
CancerSHORT syndromeMetabolic disordersInsulin resistanceOncogenesis
05
Safety considerations
Potential for off-target effects due to involvement in multiple signaling pathwaysHyperactivation of AKT signaling
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