Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A)

Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A) is a lipid kinase that phosphorylates phosphatidylinositol-4-phosphate (PI4P) to produce phosphatidylinositol 4,5-bisphosphate (PIP2), a key signaling lipid involved in a wide range of cellular processes, including signal transduction, cytoskeletal regulation, membrane trafficking, and cell proliferation. PIP5K1A activity is necessary for proper focal adhesion assembly, actin cytoskeleton organization, and is implicated in multiple signaling pathways such as Wnt. Structurally, PIP5K1A is a dimeric enzyme with a fold similar to that of protein kinases, and it requires dimerization for full activity. Dysregulation or overexpression of PIP5K1A is associated with cancers (including prostate cancer and glioma), neurological disorders, and increased cancer cell proliferation and survival

Other names

Phosphatidylinositol 4-phosphate 5-kinase type-1 alphaPIP5K1-alphaPtdIns(4)P-5-kinase 1 alphaPIP5KIalpha68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alphaphosphatidylinositol 4-phosphate 5-kinase type I alpha

Inhibition of kinase activity would reduce cellular PIP2 synthesis and downstream signaling Modulation disrupts actin cytoskeleton and cell migration