Phosphatidylinositol-4-phosphate 5-kinase type 1 beta (PIP5K1B)

Phosphatidylinositol-4-phosphate 5-kinase type 1 beta (PIP5K1B) is an enzyme that catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PI4P) to generate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a key lipid second messenger involved in the regulation of signal transduction, cytoskeleton remodeling, vesicle trafficking, cell adhesion, and motility[1][2][8]. PI(4,5)P2 directly acts as a second messenger or serves as a precursor for the production of inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG), and phosphatidylinositol 3,4,5-trisphosphate (PIP3)[1][8]. PIP5K1B activity is implicated in the regulation of actin cytoskeleton through RAC1-mediated pathways and in platelet adhesion following GPCR stimulation[1]. Genetic or epigenetic silencing of PIP5K1B is associated with cytoskeletal defects observed in Friedreich ataxia, and aberrant PIP5K1B signaling is linked to oncogenic PI3K pathway activation in cancer[1][2][4].

Other names

MSS4STM7PIP5K1-betaPIP5KIbetaphosphatidylinositol 4-phosphate 5-kinase type I betaprotein STM-7type I phosphatidylinositol 4-phosphate 5-kinase betaPI51BPI4P5K-IbPipk5btype I PIP kinase beta

Inhibition or modulation of kinase enzymatic activity to alter levels of phosphoinositide lipids (no approved drugs or clinical candidates known)