Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma (PIP5K1C)

Phosphatidylinositol-4-phosphate 5‑kinase type 1 gamma (PIP5K1C) is an enzyme that catalyzes the phosphorylation of phosphatidylinositol‑4‑phosphate to generate phosphatidylinositol‑4,5‑bisphosphate [PI(4,5)P₂], a critical lipid second messenger involved in numerous cellular processes. It is a member of the type I phosphatidylinositol phosphate kinase family. This enzyme plays key roles in regulating signal transduction pathways at the plasma membrane by controlling local PI(4,5)P₂ concentrations. Its functions include modulating actin cytoskeleton dynamics for cell movement and adhesion—particularly through interactions with focal adhesions—as well as regulating vesicle trafficking events such as exocytosis and endocytosis at synapses. In immune cells, a splice variant known as PIPKIγi5 has been shown to regulate sensitivity to interferons by interacting with STAT transcription factors; loss enhances antiviral responses by increasing IFNγ signaling. Dysregulation or overexpression has been linked to cancer progression due to altered cell migration/invasion capabilities. The gene encoding this protein is *PIP5K1C*. In humans it is widely expressed but especially important at sites requiring dynamic membrane remodeling or rapid signal relay—such as neuronal synapses and sites of immune activation. No approved therapeutic agents currently target this kinase directly; however its centrality makes it an area of interest for drug discovery efforts aimed at modulating cell motility or immune responses.[1][3][7][10]

Other names

PIP5K1CLCCS3PIP5K-GAMMAPIP5K1-gammaPIP5Kgamma[5]

Not explicitly detailed for drugs, but inhibition or modulation of this kinase would alter levels of phosphatidylinositol bisphosphates such as PI(4,5)P₂, affecting downstream signaling pathways including those involved in cell adhesion, migration, immune responses, and vesicle trafficking[1][3].