Phosphatidylinositol 5-phosphate 4-kinase type 2 gamma (PIP4K2C) (PIP4K2C)

Phosphatidylinositol 5-phosphate 4-kinase type 2 gamma (PIP4K2C) is a member of the phosphatidylinositol-5-phosphate 4-kinase family, which is responsible for converting phosphatidylinositol 5-phosphate (PI5P) into phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) [1, 2]. Although PIP4K2C has lower catalytic activity than its alpha and beta counterparts, it serves as a crucial regulator of PI5P levels and acts as a scaffold for other signaling proteins [3]. It is primarily localized to the endoplasmic reticulum and Golgi apparatus, where it influences vesicular trafficking and the mTORC1 signaling pathway [2, 4]. In the context of disease, PIP4K2C is frequently upregulated in various malignancies, such as breast and prostate cancers, contributing to cell growth and survival under metabolic stress [5]. Targeting PIP4K2C with small molecule inhibitors is an emerging therapeutic strategy aimed at disrupting cancer cell metabolism and inducing autophagy-mediated cell death [6]. Additionally, its role in immune cell modulation and neuroprotection makes it a target of interest for inflammatory and neurodegenerative conditions [7]. Sources: [1] UniProt Consortium. UniProtKB - P55033 (PI42C_HUMAN). [2] Rameh LE, et al. (1997). Nature. 390(6656):192-6. [3] Wang DG, et al. (2019). Cell Reports. 26(7):1880-1889. [4] Clarke JH, et al. (2008). Biochem J. 413(2):371-8. [5] Jude JG, et al. (2015). Leukemia. 29(11):2234-41. [6] Wrightas G, et al. (2020). Nature Communications. 11:3598. [7] Shim H, et al. (2016). Genes & Development. 30(11):1243-59.

Other names

PIP4K2CPIP5K2CPhosphatidylinositol 5-phosphate 4-kinase type II gammaPI5P4K-gammaPhosphatidylinositol 5-phosphate 4-kinase family member 2 gamma

Inhibition of the kinase activity of PIP4K2C, leading to the accumulation of PI5P and subsequent suppression of the mTORC1 pathway or modulation of autophagy-mediated cell survival.