Target intelligence / Profile preview

Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma (PIP4K2C)

Target: PIP4K2C
Molecular classification: Enzyme, Kinase, Phosphotransferase

Overview

Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma (PIP4K2C) is an enzyme that phosphorylates phosphatidylinositol-5-phosphate (PI(5)P) to generate phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P₂]. It plays a role in regulating vesicular transport, negatively regulates the insulin receptor signaling pathway, and is involved in inositol phosphate metabolism. It is being investigated as a therapeutic target for diseases such as cancer, immunological disorders, and neurodegeneration.

Other names: PIP5K2Cphosphatidylinositol-5-phosphate 4-kinase type II gamma

Mechanism of action

Kinase inhibitor

Biological functions

Regulation of vesicular transportNegative regulation of insulin receptor signaling pathwayPhosphoinositide metabolism

Disease associations

CancerImmunological disordersNeurodegeneration

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