Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU)

The phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) is a transmembrane enzyme and an essential component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase complex, mediating the post-translational attachment of GPI anchors to proteins in the endoplasmic reticulum[1][2][3][7]. PIGU helps recognize or bind the lipid portion of the GPI-anchor and organizes other subunits within the membrane, which is crucial for GPI-anchored protein biosynthesis. Mutations in PIGU can lead to neurodevelopmental disorders, and its overexpression has been linked to cancer progression through immune evasion and increased NF-κB pathway activation[3][5][6][7].

Other names

CDC91L1CDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1PIG-UGPI-anchor transamidase component PIGUGPI transamidase component PIG-UCell division cycle protein 91-like 1GAB1Protein CDC91-like 1Phosphatidylinositol glycan anchor biosynthesis class U

Catalytic subunit of GPI transamidase complex, facilitating GPI-anchor attachment to newly synthesized proteins in the endoplasmic reticulum