Phosphatidylinositol-glycan biosynthesis class F protein (PIGF)

Phosphatidylinositol-glycan biosynthesis class F protein (PIGF) is an enzyme that acts as a stabilizing subunit within the ethanolamine phosphate transferase complexes involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors, which are glycolipids that tether proteins to the cell membrane. It specifically participates in the transfer of ethanolamine phosphate to the third and second mannose residues in the GPI precursor, in association with the PIGO and PIGG proteins. PIGF’s activity is crucial for the proper post-translational modification of surface proteins, especially in blood cells, and mutations in its gene can result in multiple congenital disorders affecting nails, bones, intellectual development, and seizure susceptibility.

Other names

GPI ethanolamine phosphate transferase, stabilizing subunitPIG-FGPI ethanolamine phosphate transferase 2, stabilizing subunitGPI ethanolamine phosphate transferase 3, stabilizing subunitGPI11 homologOORS