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Target intelligence / Profile preview
Phosphatidylinositol phosphate kinase type III beta (PIKfyve)
- Target
- PIKfyve
- Molecular classification
- Lipid Kinase
01
Overview
Phosphatidylinositol phosphate kinase type III beta (PIKfyve) is a lipid kinase that phosphorylates PI(3)P to generate PI(3,5)P₂ and regulates PI(5)P levels. It is crucial for endosomal trafficking, lysosome maturation, and ion homeostasis. Dysfunction is linked to lysosomal storage diseases and neurological disorders.
- Other names
- PIP5K3Phosphoinositide kinase type III beta
02
Mechanism of action
Inhibition of PIKfyve
03
Biological functions
Endosomal traffickingLysosome maturationIon homeostasisRetrograde transport
04
Disease associations
Lysosomal storage diseasesNeurological disordersGaucher’s diseaseParkinson’s disease (potential link)
05
Safety considerations
Cytoplasmic vacuolation due to defective membrane trafficking
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