Phosphatidylserine-enriched neuronal membrane (PS-enriched neuronal membrane)

"Phosphatidylserine-enriched neuronal membrane" refers not to a single molecular target such as a receptor or enzyme but rather describes regions of the **neuronal plasma membrane** that are particularly rich in **phosphatidylserine** (PS), an acidic phospholipid predominantly located on the inner leaflet of the plasma membrane. In neurons, high concentrations of PS are essential for maintaining **membrane integrity**, supporting **synaptic vesicle fusion**, enabling efficient **neurotransmitter release**, and facilitating key signaling pathways involved in survival, growth, differentiation, and synaptic plasticity[1][2]. During apoptosis or certain pathological conditions, PS becomes exposed on the outer leaflet of the plasma membrane where it acts as an "eat-me" signal recognized by phagocytes—this process is critical both for normal tissue homeostasis and disease processes such as neurodegeneration and viral infection[3]. While crucial for many cellular functions, "phosphatidylserine-enriched neuronal membranes" do not constitute a discrete therapeutic target like receptors or enzymes but instead represent an important aspect of cellular lipid organization with broad implications in health and disease. **Note:** This entry does *not* correspond to a canonical druggable target such as an individual protein receptor. It describes a biochemical property/feature of neuron membranes. If you require information about specific proteins that bind phosphatidylserine or mediate its effects—such as annexins or TIM/TAM family receptors—please specify further.

Other names

Phosphatidylserine-rich neuronal membraneNeuronal plasma membrane enriched in phosphatidylserinePS-enriched neuron membrane