Phosphatidylserine synthase 2 (PTDSS2)

Phosphatidylserine synthase 2 (PTDSS2) is an integral membrane enzyme that catalyzes the conversion (via base-exchange reaction) of phosphatidylethanolamine to phosphatidylserine, a key anionic phospholipid in cellular membranes[1][2][3][4][5]. PTDSS2 is highly substrate-specific for phosphatidylethanolamine and does not act on phosphatidylcholine, differentiating it from its homolog phosphatidylserine synthase 1[1][2][5]. The enzyme is particularly abundant in the brain and testis, where it specializes in synthesizing docosahexaenoic acid (DHA)-containing phosphatidylserine, crucial for normal nervous system function[4]. Biologically, phosphatidylserine produced by PTDSS2 plays roles in cell signaling, apoptosis, coagulation, and maintenance of membrane structure[2][3][6]. Mutations in PTDSS2 are linked with rare genetic disorders, notably peeling skin syndrome 2 and Lenz-Majewski hyperostotic dwarfism[3]. Recent studies also indicate PTDSS2’s role in regulating the biosynthesis of membrane lipids and its potential indirect effects on sterol regulatory element-binding protein (SREBP) signaling[5].

Other names

PSS2PSS-2PtdSer synthase 2Serine-exchange enzyme II

(Not directly targeted by approved drugs as of current knowledge.) Catalyzes base-exchange conversion of phosphatidylethanolamine (PE) to phosphatidylserine (PS)[1][2][3][4][5]