Phosphodiesterase 11A (PDE11A)

Phosphodiesterase 11A (PDE11A) is an enzyme that hydrolyzes both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), converting them to their respective 5'-monophosphates. It is a member of the phosphodiesterase (PDE) superfamily and plays a role in regulating intracellular levels of cAMP and cGMP, influencing various physiological processes, including spermatogenesis, mood stabilization, social memory formation, and cell proliferation. Mutations in PDE11A are associated with Cushing's disease, adrenocortical hyperplasia, and tumorigenesis. Several splice variants exist, exhibiting different tissue expression profiles and substrate affinities. While inhibitors like BC11-38 have been identified, pharmacological characterization remains limited. Targeting PDE11A holds therapeutic potential, particularly in cancer treatment, but requires careful consideration due to its diverse roles and isoform-specific functions.

Inhibition of cAMP and cGMP hydrolysis