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Phosphodiesterase 1A (PDE1A)
- Target
- PDE1A
- Molecular classification
- Enzyme, Phosphodiesterase, Cyclic Nucleotide Phosphodiesterase, Type I: Calmodulin-dependent Phosphodiesterase
01
Overview
Phosphodiesterase 1A (PDE1A) is an enzyme that hydrolyzes cyclic nucleotides, specifically cAMP and cGMP, and its activity is stimulated by calcium/calmodulin. It plays a role in regulating various signaling pathways, particularly in cardiovascular tissues, the central nervous system, and other tissues. By controlling cAMP and cGMP levels, it influences processes such as vascular smooth muscle cell growth, survival, proliferation, and apoptosis. PDE1A is implicated in diseases such as hypertension, pulmonary arterial hypertension, metabolic syndrome, Fraser Syndrome and Nephrolithiasis.
02
Mechanism of action
Inhibition of PDE1A increases intracellular cAMP and cGMP levels.
03
Biological functions
Regulation of cAMP levelsRegulation of cGMP levelsCalcium signaling modulationVascular smooth muscle cell growthVascular smooth muscle cell survivalVascular smooth muscle cell proliferationVascular smooth muscle cell apoptosisSecond messenger regulation
04
Disease associations
Cardiovascular diseaseHypertension risk factorsPulmonary arterial hypertensionMetabolic syndromeFraser SyndromeNephrolithiasis
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