Target intelligence / Profile preview

Phosphodiesterase 1B (PDE1B)

Target: PDE1B
Molecular classification: Enzyme, Phosphodiesterase

Overview

Phosphodiesterase 1B (PDE1B) is a calmodulin-regulated enzyme critical for controlling neuronal levels of cyclic nucleotides. Its prominent expression within dopaminergic brain regions links it closely to neuropsychiatric function. Genetic deletion studies highlight its role as a negative regulator of memory formation and behavioral responses related to stress—making it an attractive target for drug development aimed at treating mood disorders such as depression.

Mechanism of action

Inhibition of PDE1B increases cAMP and cGMP levels.

Biological functions

Regulation of neuronal cAMP levelsRegulation of neuronal cGMP levelsModulation of dopamine receptor-mediated signalingHydrolysis of cyclic nucleotides

Disease associations

ImpotenceAutism Spectrum DisorderMood disordersDepression

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