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Target intelligence / Profile preview
Phosphodiesterase 2A1 (PDE2A1)
- Target
- PDE2A1
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Phosphodiesterase 2A1 (PDE2A1) is a dual-substrate phosphodiesterase enzyme that hydrolyzes both cAMP and cGMP, regulating their intracellular concentrations. It is allosterically activated by cGMP, which enhances its activity toward both substrates, especially cAMP. PDE2A1 plays a role in signaling pathways involved in memory, cognition, hormone response, and cardiovascular function. It is highly expressed in the brain and other tissues.
- Other names
- PDE2A
02
Mechanism of action
Inhibition of cAMP and cGMP hydrolysis, leading to increased intracellular levels of these cyclic nucleotides.
03
Biological functions
Hydrolyzes cAMPHydrolyzes cGMPSignal transductionRegulation of cyclic nucleotide concentrations
04
Disease associations
Cognitive impairmentNeuropsychiatric disordersCardiovascular disease
05
Interacting drugs
Pyrido[1,2,4]triazolo[4,3-a]pyrazine derivative 1 (C16H12ClN5)
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