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Target intelligence / Profile preview
Phosphodiesterase 2A3 (PDE2A3)
- Target
- PDE2A3
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Phosphodiesterase 2A3 (PDE2A3) is a mitochondrial isoform of the PDE2A enzyme, which belongs to the phosphodiesterase superfamily. PDE2A3 hydrolyzes both cAMP and cGMP, playing a crucial role in regulating intracellular signaling pathways. Its activity is allosterically regulated by cGMP, leading to enhanced cAMP hydrolysis. As a modulator of cardiac function, PDE2A3 has emerged as a potential therapeutic target for cardiovascular diseases, particularly heart failure.
- Other names
- PDE2APDE2Pde2a3cGMP-stimulated phosphodiesterase
02
Mechanism of action
Inhibition of cAMP and/or cGMP hydrolysis
03
Biological functions
Signal transductionRegulation of intracellular cAMP levelsRegulation of intracellular cGMP levelsHydrolysis of cyclic nucleotides
04
Disease associations
Heart failureCardiovascular disease
05
Safety considerations
Potential for off-target effects due to homology with other PDEsPossible cardiovascular side effects
06
Interacting drugs
EHNA (Erythro-9-(2-hydroxy-3-nonyl)adenine)
2 more in the full profile.
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