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Phosphodiesterase 3A (PDE3A)
- Target
- PDE3A
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Phosphodiesterase 3A (PDE3A) is an enzyme that hydrolyzes cAMP and cGMP, thereby regulating their intracellular concentrations and modulating various signaling pathways. It plays a critical role in cardiovascular tissues, cancer biology, and gastrointestinal physiology. Mutations in PDE3A are linked to hypertension with brachydactyly syndrome, while overexpression is implicated in breast cancer progression. Selective inhibitors like cilostazol are used as antiplatelet agents and show promise in cancer therapy.
- Other names
- cGMP-inhibited cGMP phosphodiesteraseCGI-PDEPDE3
02
Mechanism of action
Selective inhibition of PDE3A, leading to increased intracellular cAMP and cGMP levels in target cells.
03
Biological functions
cAMP hydrolysiscGMP hydrolysisRegulation of cardiac contractilityRegulation of vascular toneRegulation of platelet aggregationRegulation of cell proliferationCalcium reuptake regulation in cardiac myocytes
04
Disease associations
Hypertension with brachydactyly syndrome (HTNB)Breast cancerGastrointestinal motility disorders
05
Safety considerations
Potential for cardiovascular effects due to vasodilatory and inotropic actions
06
Interacting drugs
Cilostazol
07
Biomarkers
PDE3A expression levels in breast cancer tissueICC density in gastrointestinal tissue
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